New Protein Discovery Could Help Understand DNA Replication and Cancer, نیا پروٹین دریافت ڈی این اے نقل اور کینسر کو سمجھنے میں مددگار":DNA Replication Discovery Protein USP50 Study Cancer Research 2024 DNA Repair Mechanisms New Genetic Breakthrough USP50 and DNA Enzymes Hereditary Conditions and DNA

New Protein Discovery Could Help Understand DNA Replication and Cancer,

نیا پروٹین دریافت ڈی این اے نقل اور کینسر کو سمجھنے میں مددگار":

Scientists have found a key protein, **USP50**, that controls DNA replication. It makes sure enzymes work right, even when DNA gets in the way. This could help us understand diseases like early aging and cancer.

USP50 does more than just help with DNA replication. It also protects **telomeres**, the ends of chromosomes. A study in *Nature Communications* shows how USP50 manages enzymes during DNA replication and telomere maintenance.

Professor Jo Morris from the University of Birmingham led this research. She and her team found out how USP50 picks which enzymes to use. This gives us a better look at how DNA replication works.

A Deeper Understanding of Cellular Mechanics

"Our research shows how cells use specific enzymes for DNA replication," says Professor Jo Morris. "With so many enzymes, it's important to control them. USP50 is key to this control, helping us understand genetic diseases."

Without USP50, cells can't replicate DNA properly. They use enzymes in a way that causes problems. This can lead to serious genetic diseases.

 A Surprising Twist in DNA Replication

Morris says, "We found that without USP50, DNA replication can stop. Cells have a delicate balance of enzymes. Any imbalance can cause big problems."

**Professor Simon Reed** from Cardiff University's Division of Cancer and Genetics talks about the findings. "This research shows how USP50 keeps our DNA stable. It could lead to new ways to treat genetic diseases. Thank you to all who worked on this."

 Future Implications for Medical Science

This discovery could lead to new treatments for DNA repair. By understanding USP50's role, scientists might find ways to fix genetic problems. This could help fight cancer and early aging.

The study, *"USP50 Suppresses Alternative RecQ Helicase Use and Deleterious DNA2 Activity During Replication,"* was published on **16th September 2024** in *Nature Communications*.

 Key Reference:

**Hannah L. Mackay, Helen R. Stone, George E. Ronson, Katherine Ellis, Alexander Lanz, Yara Aghabi, Alexandra K. Walker, Katarzyna Starowicz, Alexander J. Garvin, Patrick Van Eijk, Stefan A. Koestler, Elizabeth J. Anthony, Ann Liza Piberger, Anoop S. Chauhan, Poppy Conway-Thomas, Alina Vaitsiankova, Sobana Vijayendran, James F. Beesley, Eva Petermann, Eric J. Brown, Ruth M. Densham, Simon H. Reed, Felix Dobbs, Marco Saponaro, and Joanna R. Morris.**

**DOI:** 10.1038/s41467-024-52250-4